How Does CBD Get Metabolized in The Body?

How Does CBD Get Metabolized in The Body?

Metabolism is the process that explains how the food is broken down and absorbed by the body. In case of CBD, the metabolism depends on various factors that include the dosage of CBD, its bioavailability, and the way of administration.

When you ingest CBD, it gets metabolized in the liver. There it gets converted into several metabolites that get excreted from the body via the biliary system. In this post, we will look more closely at the metabolism of CBD.

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About Metabolism

Metabolism is the process by which the body converts its chemical compounds via enzymes. These enzymes are a form of protein that stays in the cells of the body and initiates chemical reactions.

A majority of the metabolism process is carried out in the gut wall, blood plasma, and lungs. The key enzyme group involved in this process is termed as “cytochrome P450.”

How Does Metabolism Take Place In The Body?

Metabolism is bifurcated in two parts such as phase 1 and phase 2. In phase 1, the body goes via a process termed as oxidation. In phase 2, the substance becomes more water-soluble and is excreted from your body. The substance possesses very little pharmacological activity and becomes less effective in this phase.

So, when you eat food, it goes to the liver. Your liver is the largest organ and the chemical processing region of the body. This is the stage when phase 1 and phase 2 metabolisms occur. The substance starts to lose its impact and is expelled from the body.

How is CBD Metabolized In The Body?

To learn about its therapeutic results, it is important to understand how CBD gets metabolized and how it works with other substances.

When you ingest any CBD enriched product, then it travels to the liver. Its metabolization starts in this organ. It goes through the two metabolic phases as Phase 1 and Phase 2. It gets transformed into two useful chemical compounds as 6-OH-CBD and 7-OH-CBD in the liver.

What is The Role of Cytochrome P450 In the Metabolism Of CBD?

Enzymes have a big role to play in the metabolism of CBD. Cytochrome p450 is a set of enzymes that administers the metabolism of CBD in the liver.

While CBD goes through metabolism, it shows an inhibitory impact on the group of enzymes for other types of chemical compounds. The presence of this chemical compound in the system restricts the absorption of other substances


CBD is widely studied for its impact on various health conditions such as insomnia, anxiety, severe pain, depression, and more. This study requires understanding how the metabolism happens, what metabolites are formed, the varying target tissues involved, and the impact on physiological functions. This understanding will help in the effective investigation of the therapeutic potential of CBD.